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目的:优选复方参芪软胶囊的醇沉工艺。方法:采用正交试验设计,以药液中总多糖的含量和干膏得率为指标,考察浓缩液的相对密度、醇沉浓度、静置时间、醇沉温度对醇沉效果的影响。结果:最佳醇沉工艺为药液浓缩至相对密度1.10,加95%乙醇至含醇量为60%,室温下静置48 h。结论:优选的复方参芪软胶囊醇沉工艺简便易行,适用于实际生产配制。
Objective: To optimize alcohol Shen Shen soft capsule Shen technology. Methods: Using orthogonal experimental design, the content of total polysaccharide and the dry extract yield were taken as indexes to study the effects of relative density, alcohol concentration, standing time and alcohol precipitation temperature on alcohol precipitation. Results: The optimum alcohol precipitation process was liquid concentration to a relative density of 1.10, 95% ethanol to alcohol content of 60%, at room temperature for 48 h. Conclusion: The preferred compound Shenqi soft capsule alcohol precipitation process is simple and convenient, suitable for the actual production of preparation.