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探讨碱性成纤维细胞生长因子（ｂＦＧＦ）对肠缺血后细菌易位的影响，为肠源性感染的防治及脏器功能的保护寻找新的手段。将基因重组的ｂＦＧＦ应用于肠系膜上动脉夹闭大鼠，观察它对肠道细菌易位及脏器功能的影响。结果：ｂＦＧＦ治疗组大鼠伤后６小时脏器细菌培养阳性率明显降低（Ｐ＜０．０５）；谷丙转氨酶、谷草转氨酶含量与单纯夹闭组相比明显降低（Ｐ＜０．０５）；血尿素氮含量与假手术组比较无显著性差异；病理观察见肠粘膜损伤明显减轻。提示：ｂＦＧＦ对肠缺血早期肠道细菌易位的减少及肝肾功能的保护具有显著作用，这一结果为临床创伤、肠缺血损伤的早期治疗提供一种新的启示
To investigate the effect of basic fibroblast growth factor (bFGF) on bacterial translocation after intestinal ischemia and find new ways for the prevention and treatment of intestinal infection and the protection of organ function. The gene recombinant bFGF was applied to superior mesenteric artery occlusion rats to observe its effects on intestinal bacterial translocation and organ function. Results: The positive rate of bacterial culture in organs of bFGF treatment group was significantly lower than that of the control group (P <0.05) at 6 hours after injury (P <0.05). The levels of alanine aminotransferase and aspartate aminotransferase were significantly decreased (P <0.05) ; Blood urea nitrogen content compared with the sham operation group no significant difference; pathological observation of intestinal mucosal injury was significantly reduced. It is suggested that bFGF plays a significant role in the reduction of intestinal bacterial translocation in the early stage of intestinal ischemia and the protection of liver and renal function, and this result provides a new revelation for the early treatment of clinical trauma and intestinal ischemia injury