论文部分内容阅读
目的:为了研究大黄对小儿胃肠功能衰竭的作用机制。为小儿胃肠功能障碍的防治提供理论依据。方法:将68例胃肠功能衰竭患儿随机分为大黄治疗组38例和常规治疗组30例。大黄治疗组在常规治疗组的基础上给予大黄粉敷脐治疗。1个月~1岁10~20 g/次,1~3岁20~30 g/次,3岁以上30~50 g/次,用蜜糖调匀放置纱布块上,敷于脐部。每日更换1次,连用3~5次。入院时和入院后72 h检测TNF-a、IL-1、IL-6、血乳酸。TNF-a、IL-1、IL-6采用ELISA测定。血乳酸采用乳酸检测仪(美国)测定,并选择30例健康儿为正常对照组。结果:大黄对胃肠功能衰竭患儿细胞因子有明显降低作用。能降低MODS发生率。两组对照均有统计学意义。结果:大黄粉敷脐疗法对小儿胃肠功能衰竭有较好的疗效。其主要作用机制是大黄对细胞因子有拮抗作用。
Objective: In order to study the mechanism of rhubarb on pediatric gastrointestinal failure. To provide a theoretical basis for the prevention and treatment of gastrointestinal dysfunction in children. Methods: 68 cases of children with gastrointestinal failure were randomly divided into rhubarb treatment group 38 cases and conventional treatment group 30 cases. Rhubarb treatment group in the conventional treatment group given rhubarb powder umbilical treatment. 1 month ~ 1 year old 10 ~ 20 g / time, 1 ~ 3 years old 20 ~ 30 g / time, 3 years old and above 30 ~ 50 g / time, place honey evenly on the gauze block, deposited in the navel. Daily change 1, once every 3 to 5 times. TNF-a, IL-1, IL-6 and blood lactate were detected at admission and 72 h after admission. TNF-a, IL-1, IL-6 were measured by ELISA. Blood lactate using lactic acid detector (USA) determination, and select 30 healthy children as normal control group. Results: Rhubarb significantly reduced the cytokines in children with gastrointestinal failure. Can reduce the incidence of MODS. Two groups of control were statistically significant. Results: Rhubarb powder umbilical therapy for children with gastrointestinal failure have a good effect. Its main mechanism of action is that rhubarb antagonizes cytokines.