论文部分内容阅读
恶性疟原虫基因表达的修饰已被抗原变异及不同发育时期rRNA表达差异所证明,而且寄生虫侵入方式的改变,可能也是基因表达修饰的结果。恶性疟原虫Dd_2株以唾液酸依赖途径侵入红细胞,用神经氨酸酶处理红细胞除去唾液酸将导致Dd_2株的侵入减少95％。但是,如果将疟原虫保存在神经氨酸酶处理过的红细胞中10—12天,Dd_2-Nm亚群出现,它在神经氨酸酶处理和未处理的红细胞中均以同样比率生长。本文作者采用表达
Plasmodium falciparum gene expression modification has been antigenic variation and rRNA expression differences at different development stages to prove, and changes in parasite invasion may also be the result of gene expression modification. Plasmodium falciparum Dd_2 invaded erythrocytes in a sialic acid-dependent manner, and neuraminidase treatment of erythrocytes to remove sialic acid resulted in a 95% reduction in intrusion of Dd 2 strain. However, if the P. falciparum was present in neuraminidase-treated erythrocytes for 10-12 days, a subset of Dd_2-Nm appeared, which grew in both neuraminidase-treated and untreated erythrocytes at the same rate. The author uses the expression