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临床和尸检研究表明,慢性肠道炎症患者易并发血栓栓塞症,这是由于凝血机制变更而引起的血液高凝状态所致,主要变化为血小板过多和血浆纤维蛋白原增加。这些病人出现的血小板增多是否与血小板聚集作用增强,进而形成血栓有内在联系尚不清楚。通过检测血小板内物质如血小板第Ⅳ因子(PE4)和β-血小板球蛋白可测定血小板的聚集活性。血小板在聚集时释放
Clinical and autopsy studies have shown that patients with chronic intestinal inflammation are more likely to develop thromboembolism due to hypercoagulability of the blood caused by changes in coagulation mechanisms, with the main changes being thrombocytopenia and increased plasma fibrinogen. It is unclear whether these patients have thrombocytosis with increased platelet aggregation and subsequent thrombus formation. Platelet aggregation activity can be measured by detecting platelet-derived substances such as platelet factor IV (PE4) and β-thromboglobulin. Platelets are released when they accumulate