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目的 :研究p53蛋白表达与膀胱移行细胞癌生物学行为及预后的关系。方法 :应用免疫组织化学LSAB法检测50例膀胱移行细胞癌组织中p53蛋白的表达。结果 :6例正常膀胱粘膜组织中未发现p53蛋白的表达 ,50例膀胱移行细胞癌中 p53蛋白阳性表达率为64%。p53蛋白阳性表达与肿瘤的病理分级、临床分期、复发率及患者术后生存率关系密切。结论 :检测p53蛋白表达对判断膀胱移行细胞癌的恶性程度及预测预后有重要参考价值
Objective: To investigate the relationship between p53 protein expression and biological behavior and prognosis of bladder transitional cell carcinoma. Methods: The expression of p53 protein in 50 cases of bladder transitional cell carcinoma was detected by immunohistochemistry LSAB method. Results: The expression of p53 protein was not found in 6 cases of normal bladder mucosa. The positive rate of p53 protein in 50 cases of bladder transitional cell carcinoma was 64%. The positive expression of p53 protein was closely related to the pathological grade, clinical stage, recurrence rate and postoperative survival rate of the patients. Conclusion: Detecting the expression of p53 protein has an important reference value in judging the malignant degree of bladder transitional cell carcinoma and predicting the prognosis