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OBJECTIVES:We sought to test the hypothesis that C-reactive protein(CRP)can predict the recurrence of atrial fibrillation(AF)after successful electrical cardioversion(CV). BACKGROUND: In patients with AF, CRP levels are predictive of immediate failure of CV. METHODS: We prospectively measured high-sensitivity CRP in 67 patients with AF or atrial flutter who underwent successful electrical CV. RESULTS: At one-month follow-up, 22 patients(33%)had recurrence of their arrhythmia. Arrhythmia recurrence was associated with significantly higher pre-CV CRP levels(odds ratio[OR] 1.84; 95%confidence interval[CI] 1.14 to 2.98; p=0.013 )even after adjusting for age(OR 2.22; 95%CI 1.25 to 3.93; p=0.006), for gender(OR 1.89; 95%CI 1.16 to 3.09; p=0.011), or duration of arrhythmia(OR 1.86; 95%CI 1.13 to 3.07; p=0.015). On multivariate analysis, CRP was the only independen t predictor of arrhythmia recurrence(OR 2.19; 95%CI 1.05 to 4.55; p=0.036). CONCLUSIONS: Our data suggest that high levels of CRP are associated with an increa sed risk of recurrence of AF within one month. These data support the hypothesis that antiinflammatory interventions may help in maintenance of normal sinus rhy thm after CV. These data also may have implications for the identification of pa tients who are most likely to experience substantial benefit from CV therapy for AF.
OBJECTIVES: We sought to test the hypothesis that C-reactive protein (CRP) can predict the recurrence of atrial fibrillation (AF) after successful electrical cardioversion (CV). BACKGROUND: In patients with AF, CRP levels are predictive of immediate failure of CV RESULTS: At one-month follow-up, 22 patients (33%) had recurrence of their arrhythmia. Arrhythmia recurrence was associated with significantly higher pre-CV CRP levels (odds ratio [OR] 1.84; 95% confidence interval [CI] 1.14 to 2.98; p = 0.013) even after adjusting for age (OR 2.22; 95% CI 1.25 to 3.93; ), for gender (OR 1.89; 95% CI 1.16 to 3.09; p = 0.011), or duration of arrhythmia (OR 1.86; 95% CI 1.13 to 3.07; p = 0.015). On multivariate analysis, CRP was the only independen t predictor of arrhythmia recurrence (OR 2.19; 95% CI 1.05 to 4.55; p = 0.036) CONCLUSIONS: Our data suggest that high levels of CRP are associated with an increa sed risk of recurrence of AF within one month. These data support the hypothesis that antiinflammatory interventions may help in maintenance of normal sinus rhy thm after CV. These data also may have implications for the identification of pa tients who are most likely to experience substantial benefit from CV therapy for AF.