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Melzack 与 Wall 的闸门学说提出这样一个想法,即刺激传入神经纤维可缓解疼痛。根据这一概念,刺激粗大的传入 A 纤维,(它不传导疼痛)减少外周疼痛感受器经过小的有髓鞘和无髓鞘 C 纤维传入大脑的痛觉刺激,这一理论使疼痛感觉的易变性得到初步的解释。用脉宽100~200μs 的电刺激,刺激大的 A 纤维(而不是 C 纤维)可减少痛觉,用这项技术治疗慢性疼痛获得了一定成功。开始用经皮外刺激器,最近通过用硬膜外电极进行直接刺激脊髓来实现的。少数病人减少了间歇跛行甚至当应用神经刺激时腿部有温暖的感觉。进一步的工作
The gating theory of Melzack and Wall raises the idea that stimulating afferent nerve fibers can ease pain. According to this concept, the stimulation of gross afferent A fibers (which do not transmit pain) reduces the painful sensation of peripheral pain receptors that pass through the small myelinated and unmyelinated C fibers into the brain Denaturation has been the initial explanation. Electrical stimulation with a pulse width of 100-200 μs stimulates large A fibers instead of C fibers to reduce pain and some success with this technique for the treatment of chronic pain. Beginning with percutaneous exciters has recently come about by directly stimulating the spinal cord with epidural electrodes. Few patients have reduced intermittent claudication and have a warm feel on the legs even when applying nerve stimulation. Further work