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背景单项血清肝酶增高的病因长期不明，某校学生中发生381例以此为主要特征的肝损害病人。目的为初步阐明这一疾病的病因、传播和病变。方法流行病学调查、临床观察、肝活组织检查以及血清和粪便的聚合酯链反应检测。结果根据临床和检测结果可排除中毒引起，已知肝炎病毒的血清标志物均明性。症状轻微，病程多急性、少数可超过6个月。肝组织呈汇管区炎。散在发病后进行3次人群普查，3个月累计发病率占流行人群的60．7％。分析认为经日常生活接触和多次小范围的食物传播。采取以切断传播为主的预防措施，2个月后流行控制。由病人的急性期血清和潜伏期粪便提取DNA，检出与一种新近报告的血传性病毒（TTV）有同源性的基因片段。结论可能是另一种肠传型肝炎病毒引起的非甲非戊型病毒性肝炎。
Background The cause of elevated serum levels of single-enzyme-linked immunosorbent assay (HBV) is unknown for a long time. A total of 381 patients with liver dysfunction were included in this study. The purpose is to initially elucidate the etiology, spread and pathology of the disease. Methods Epidemiological investigation, clinical observation, liver biopsy and detection of polymerase chain reaction in serum and feces. Results According to clinical and test results can be ruled out poisoning, known hepatitis virus serum markers are clear. Minor symptoms, more acute course, a few can be more than 6 months. Liver tissue was portal area inflammation. After the onset of 3 times the population census, cumulative incidence of 3 months accounted for 60.7% of the popular population. Analyzes suggest that contact with the daily life and many small-scale food distribution. Preventive measures based on cut off of transmission were adopted and epidemic control was given after 2 months. DNA was extracted from the patient’s acute phase serum and incubation period stool, and a fragment of the gene homologous to a recently reported blood-borne virus (TTV) was detected. The conclusion may be caused by another enteric hepatitis virus non-A non-hepatitis E virus.