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目的:探讨胃癌组织中VEGF、CD34、VEGF-C和VEGFR-3的表达情况及临床意义。方法:采用免疫组化方法测定81例胃癌组织VEGF、CD34、VEGF-C和VEGFR-3表达情况,并结合患者的临床病理资料进行分析。结果:81例胃癌组织中MVD平均值为(42.95±14.79)个/视野,范围为13.00～68.33个/视野,VEGF、VEGF-C、VEGFR-3阳性表达率分别为74.1%、64.2%、67.9%。VEGF的表达与肿瘤的TNM分期、浸润深度、淋巴结转移有关,CD34的表达与肿瘤的分化程度、TNM分期、浸润深度、淋巴结转移有关,VEGF-C的表达与肿瘤的分化程度、浸润深度、淋巴结转移有关,VEGFR-3的表达与肿瘤的浸润深度、淋巴结转移有关。结论:VEGF、CD34、VEGF-C和VEGFR-3的表达与胃癌的浸润转移密切相关。
Objective: To investigate the expression of VEGF, CD34, VEGF-C and VEGFR-3 in gastric cancer and its clinical significance. Methods: The expressions of VEGF, CD34, VEGF-C and VEGFR-3 in 81 cases of gastric cancer were detected by immunohistochemistry and analyzed with clinicopathological data. Results: The MVD in 81 cases of gastric cancer was (42.95 ± 14.79) / field, ranging from 13.00 to 68.33 / field. The positive rates of VEGF, VEGF-C and VEGFR-3 were 74.1%, 64.2% and 67.9 %. The expression of VEGF was correlated with TNM stage, depth of invasion and lymph node metastasis. The expression of CD34 was correlated with tumor differentiation, TNM stage, depth of invasion and lymph node metastasis. The expression of VEGF-C correlated with tumor differentiation, depth of invasion, lymph node Metastasis, VEGFR-3 expression and tumor invasion depth, lymph node metastasis. Conclusion: The expressions of VEGF, CD34, VEGF-C and VEGFR-3 are closely related to the infiltration and metastasis of gastric cancer.