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科学家对人艾滋病病毒(HIV)越了解,就越有更多的机会来设计药物和疫苗,以防止HIV攻击人类细胞。在病毒的生活周期中有几个关键期对干扰易感。其中一个是病毒与称为T4淋巴细胞的白细胞结合时期。波士顿的哈佛医学院、哈佛公共卫生学校的一组研究人员正在详细研究其结合过程。Joseph Sodroski、William Haseltine等开始鉴别病毒被膜蛋白参与结合的部位和病毒如何进入细胞。他们的研究还为HIV如何杀死所攻击的细胞提供了解释。当HIV结合T4淋巴细胞时,称为gp120的病毒被膜蛋白附着在称为CD4的受体分子上,
The more scientists understand the human immunodeficiency virus (HIV), the more opportunities they have for designing drugs and vaccines to prevent HIV from attacking human cells. There are several key phases in a virus’s life cycle that are susceptible to interference. One of these is the virus’s leukocyte binding phase called T4 lymphocytes. A team of researchers at Harvard School of Medicine and Harvard School of Public Health in Boston are studying the process in detail. Joseph Sodroski, William Haseltine and others began to identify the viral envelope proteins involved in the binding site and how the virus enters the cell. Their research also provides an explanation for how HIV kills the cells it attacks. When HIV binds to T4 lymphocytes, the viral envelope protein, called gp120, is attached to a receptor molecule called CD4,