Bone marrow mesenchymal stem cells induce M2 microglia polarization through PDGF-AA/MANF signaling

• 作 者: Fan Yang Wen-Bin Li Ye-Wei Qu
• 机 构: DepartmentofNeurology,DepartmentofRespiratoryMedicine
• 出 处: 世界干细胞杂志:英文版(电子版)
• 发表日期: 2020年7期
• 关键词: Mesencephalic astrocyte-derived neurotrophic factor Bone marrow mesenchymal stem

BACKGROUND Bone marrow mesenchymal stem cells(BMSCs)are capable of shifting the microglia/macrophages phenotype from M1 to M2,contributing to BMSCsinduced brain repair.However,the regulatory mechanism of BMSCs on microglia/macrophages after ischemic strok