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目的 :观察尼索地平缓释胶囊对高血压及稳定性心绞痛的疗效。方法 :76例 1级和 2级高血压并稳定性心绞痛病人随机分为尼索地平组 (40例 )和硝苯地平组 (36例 ) ,分别给予尼索地平缓释胶囊 10～ 2 0mg ,与硝苯地平控释片 30～ 6 0mg ,均po ,qd× 6wk。结果 :尼索地平组降压总有效率92 % ,硝苯地平组为 94 %。 2组间疗效无显著差异(P >0 .0 5 )。 2组治疗后 2 4h、日间及夜间平均SBP和DBP均较治疗前显著下降 (P <0 .0 1)。尼索地平组治疗后SBP ,DBP的谷/峰比值 (T/P)分别为6 0 .5 %及 5 1.2 % ,硝苯地平组为 6 3.8%及 5 4.8%(P >0 .0 5 )。 2组治疗后心绞痛发作次数、持续时间、硝酸甘油耗量及心电图蹬车运动负荷试验各指标均较治疗前明显改善 ,组间无显著差异。结论 :尼索地平缓释胶囊能有效降压 ,改善稳定性心绞痛病人的症状和运动能力 ,且耐受性良好。
Objective: To observe the curative effect of nisoldipine sustained release capsules on hypertension and stable angina pectoris. Methods: A total of 76 patients with grade 1 and 2 hypertension and stable angina pectoris were randomly divided into nisoldipine group (n = 40) and nifedipine group (n = 36) And nifedipine controlled release tablets 30 ~ 60mg, all po, qd × 6wk. Results: The total effective rate of nisoldipine group was 92%, nifedipine group 94%. There was no significant difference between the two groups (P> 0.05). The average SBP and DBP both at 2 and 4 hours after treatment in both groups were significantly lower than those before treatment (P <0.01). In the nisoldipine group, the trough / peak ratio (T / P) of SBP and DBP was 65.5% and 52.2%, respectively, while the nifedipine group was 6.83% and 5.48% (P> 0.05) ). After treatment, the number of angina attacks, duration, nitroglycerin consumption and electrocardiogram treadmill exercise load test were significantly improved than before treatment, no significant differences between groups. Conclusion: Nisoldipine sustained-release capsules can effectively depressurization and improve the symptoms and exercise capacity of patients with stable angina and are well tolerated.