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本文报告28例青少年血吸虫病性侏儒症患者的内分泌改变。男性患者血浆睾酮、雌二醇浓度均显著低于对照值;女性患者血浆睾酮显著高于对照值,雌二醇低于对照值,但无统计学意义。患者的血清黄体生成素、甲状腺素。血浆皮质醇、生长激素浓度均在正常范围。促黄体素释放激素垂体兴奋试验,女性6例中有2例呈低差反应,男性7例中有5例反应异常。血吸虫病性侏儒症患者的骨生长与性发育障碍可能与失长介质素合成与分泌不足及性腺发育不良有关,并与垂体性侏儒症的内分泌功能状态有一定的差异。
This article reports the endocrine changes in 28 cases of juvenile schistosomiasis dwarfism patients. Male patients with plasma testosterone and estradiol concentrations were significantly lower than the control value; female patients with plasma testosterone was significantly higher than the control value, estradiol lower than the control value, but no statistically significant. Patients with serum luteinizing hormone, thyroxine. Plasma cortisol, growth hormone concentrations were in the normal range. Luteinizing hormone releasing hormone pituitary excitability test, 6 cases of women in 6 cases showed a low response, 5 cases of male 7 cases were abnormal. Schistosomiasis dwarfism patients with bone growth and sexual development disorders may be related to the lack of synthesis and growth of the lack of growth hormone and hypogonadal dysgenesis, and pituitary dwarfism endocrine function state has some differences.