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目的报道我院1例诊断为成人肝母细胞瘤的病例,并检索国内文献,收集其随访资料,对其进行单因素及多因素分析,以探讨影响成人肝母细胞瘤的预后因素,为治疗提供参考。方法回顾性分析我院收治的1例及检索国内文献报道的41例成人肝母细胞瘤患者的临床资料,使用SPSS 19.0软件进行统计分析,采用KaplanMeier法计算生存率及中位生存时间,进行单因素分析;各因素亚组间生存分析比较采用log-rank检验,对差异统计学意义的因素进行Cox回归分析。结果 Log-rank检验证实,发病年龄≥70岁、多发肿瘤、姑息性治疗、病理学检测结果为胚胎型者生存率明显降低(P<0.05);Cox多因素分析并未发现其独立危险因素。结论成人肝母细胞瘤的病理组织学类型、肿瘤数目及治疗方式可能是影响肝母细胞瘤患者预后的危险因素,有待进一步积累大样本量证实。
Objective To report a case of diagnosis of adult hepatoblastoma in our hospital and to retrieve the domestic literatures and to collect the follow-up data of them. Univariate and multivariate analysis were conducted to explore the prognostic factors affecting adult hepatoblastoma. for reference. Methods Retrospective analysis of 1 case admitted to our hospital and retrieval of 41 cases of adult hepatoblastoma reported in domestic literature were analyzed by SPSS 19.0 software. The KaplanMeier method was used to calculate the survival rate and median survival time. Factor analysis; Survival analysis of each factor subgroups was compared by log-rank test, Cox regression analysis was used to analyze the differences of statistical significance. Results The Log-rank test confirmed that the incidence of multiple tumors and palliative treatment was significantly lower in the embryo-type patients than in the patients aged 70 years or older (P <0.05). Cox multivariate analysis showed no independent risk factors. Conclusion The histopathological types, the number of tumors and the treatment methods in adult hepatoblastoma may be risk factors for the prognosis of hepatoblastoma. It is necessary to further accumulate large samples.