【摘 要】
：
采用一步法在二异丙基乙胺存在下由2-氨基-1-苯乙酮盐酸盐、芳香醛和巯基乙酸三组分反应高效合成了噻唑烷酮.该反应显示出很好的化学选择性.首先2-氨基-1-苯乙酮的N原子与芳
【机 构】
：
巴巴萨海布·安贝卡马拉特瓦达大学化学系,拉贾拉姆学院,
论文部分内容阅读
采用一步法在二异丙基乙胺存在下由2-氨基-1-苯乙酮盐酸盐、芳香醛和巯基乙酸三组分反应高效合成了噻唑烷酮.该反应显示出很好的化学选择性.首先2-氨基-1-苯乙酮的N原子与芳香醛选择性反应生成席夫碱,然后巯基乙酸的S原子亲核进攻席夫碱的C原子,最后N原子与羧酸基团环加成生成噻唑烷酮.合成的化合物用光谱技术进行了表征.
The thiazolidone was efficiently synthesized by one-step reaction of 2-amino-1-acetophenone hydrochloride, aromatic aldehyde and thioglycolic acid in the presence of diisopropylethylamine.This reaction showed good chemical Selectivity.Second, 2-amino-1-acetophenone N atoms and aromatic aldehydes selective reaction Schiff base, and then S-thiol sulfonic acid Schiff base nucleophilic attack C atoms, the last N atoms and carboxylic acid groups Cyclic addition of thiazolidinones results in the synthesis of compounds using spectroscopic techniques.
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