论文部分内容阅读
为了解血清TNF_α和IL_10的水平与新生儿感染状态和预后的关系 ,将2000年1月～2002年1月新生儿病房收治的足月儿207例 ,分为败血症组82例 ,一般感染组98例 ,非感染组27例 ,用ELISA法检测血清TNF_α和IL_10水平。结果显示 ,败血症组的TNF_α、IL_10水平显著高于无感染组和一般感染组 ;血培养阳性和血培养阴性的败血症组之间TNF_α和IL_10水平差异无显著性 ;IL_10的水平和IL_10/TNF_α的比值在恶化或死亡的感染病例中显著升高。提示TNF_α和IL_10水平可能更敏感地反映机体感染的情况及预测预后
To understand the relationship between serum TNF-α and IL-10 levels and neonatal infection status and prognosis, 207 full-term infants admitted to neonatal ward from January 2000 to January 2002 were divided into sepsis group (n = 82) and general infection group Cases, non-infected group of 27 patients with serum TNF-α and IL_10 levels by ELISA. The results showed that the levels of TNF_α and IL_10 in sepsis group were significantly higher than those in non-infected group and general infection group. The levels of TNF_α and IL_10 in serum-positive and blood-negative sepsis groups were not significantly different. The levels of IL_10 and IL_10 / TNF_α The ratio is significantly higher in cases of worsening or dying infections. These results suggest that the levels of TNF_α and IL_10 may reflect the infection of the body more sensitively and predict the prognosis