论文部分内容阅读
气道重塑(airway remodeling)是支气管哮喘(简称哮喘)的一个重要病理特征,主要表现为气道结构的改变,包括气道平滑肌细胞(airway smooth muscle cells,ASMCs)增生与肥大、上皮下纤维化、气道上皮细胞脱落、黏液腺和杯状细胞增生等[1-2]。多种结构细胞(如ASMCs、成纤维细胞、气道上皮细胞等)、炎症细胞(嗜酸粒细胞、中性粒细胞、T淋巴细胞等)及其分泌的细胞因子、趋化因子和细胞外基质(extracellular matrix,ECM)参与气道重塑过
Airway remodeling is an important pathological feature of bronchial asthma (asthma), mainly manifested as changes in airway structure, including airway smooth muscle cells (ASMCs) proliferation and hypertrophy, subcutaneous fibers , Airway epithelial cells shedding, mucus gland and goblet cell proliferation [1-2]. A variety of structural cells (such as ASMCs, fibroblasts, airway epithelial cells, etc.), inflammatory cells (eosinophils, neutrophils, T lymphocytes, etc.) and its secretion of cytokines, chemokines and extracellular Extracellular matrix (ECM) is involved in airway remodeling