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目的探究雄激素调节蛋白在高血压肾病中的诊断意义。方法 200例高血压肾病患者,根据肾脏损害的情况分成高血压肾病早期组与高血压肾病晚期组,各100例。另选取50例在本院进行健康体检的正常人作为对照组,对比三组雄激素调节蛋白水平;对患者进行问卷调查,探究影响雄激素调节蛋白水平的因素。结果高血压肾病早期组的血肌酐和雄激素调节蛋白的检测值明显高于对照组,差异有统计学意义(P<0.05);两组的尿素氮和尿微量白蛋白检测值对比,差异无统计学意义(P>0.05);高血压肾病晚期组的各项检测值均高于对照组,差异有统计学意义(P<0.05);高血压肾病早期组与高血压肾病晚期组的检测值对比,差异均有统计学意义(P<0.05)。患者高血压病史、吸烟、饮酒是影响其体内雄激素调节蛋白水平的因素(P<0.05)。结论高血压肾病患者体内的雄激素调节蛋白水平远高于正常人,能作为诊断高血压肾病的指标;且患者的生活习惯与高血压病史都会不同程度影响雄激素调节蛋白的水平。
Objective To investigate the diagnostic significance of androgen regulatory protein in hypertensive nephropathy. Methods 200 patients with hypertensive nephropathy were divided into two groups according to their renal damage: early hypertensive nephropathy group and late hypertensive nephropathy group, with 100 cases each. Another 50 healthy people in our hospital were selected as control group and compared with three groups of androgen regulatory protein levels; the patients were surveyed to explore the factors that affect androgen regulatory protein levels. Results The levels of serum creatinine and androgen regulatory protein in the early stage of hypertensive nephropathy group were significantly higher than those in the control group (P <0.05). There was no significant difference between the two groups in the measured values of urea nitrogen and urine microalbumin (P> 0.05). The detection values of late-stage hypertensive nephropathy group were higher than those of the control group, the difference was statistically significant (P <0.05); compared with the late-stage hypertensive nephropathy group , The differences were statistically significant (P <0.05). The history of patients with hypertension, smoking, alcohol consumption are the factors that affect the level of androgen regulatory protein (P <0.05). Conclusions The level of androgen regulatory protein in patients with hypertensive nephropathy is much higher than that in normal people and can be used as an index to diagnose hypertensive nephropathy. And the patients’ living habits and the history of hypertension all affect the level of androgen regulatory protein.