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目的:探讨盐酸帕罗西汀对脑卒中后抑郁及神经功能恢复的影响。方法:将合并抑郁障碍的82例脑卒中患者随机分为观察组(盐酸帕罗西汀治疗组)和对照组(常规治疗组)。于治疗前及治疗后2、4、8周对两组患者分别采用汉密顿焦虑量表(HAMA)、神经功能缺损量表及修订的Barthel指数量表(MBI)进行评定。结果:观察组治疗4周和8周后评分较治疗前明显降低(P<0.05),对照组治疗后8周后评分较治疗前明显降低(P<0.05);治疗4周和治疗8周后,两组差异有统计学意义(P<0.05)。治疗8周后,两组患者神经功能缺损评分和MBI均较治疗前明显改善,观察组改善程度优于对照组,差异有统计学意义(P<0.05)。结论:盐酸帕罗西汀对脑卒中后合并抑郁障碍患者的抗抑郁效果肯定,且能促进患者神经功能的恢复,提高其日常活动能力,用药安全。
Objective: To investigate the effect of paroxetine on depression and neurological function after stroke. Methods: 82 stroke patients with depression were randomly divided into observation group (paroxetine hydrochloride treatment group) and control group (conventional treatment group). Before treatment and 2, 4, 8 weeks after treatment, the two groups were evaluated by Hamilton Anxiety Scale (HAMA), Neurological Deficit Scale and Modified Barthel Index Scale (MBI). Results: After 4 weeks and 8 weeks of treatment, the score of the observation group was significantly lower than that before treatment (P <0.05), and the score of the control group after 8 weeks was significantly lower than that before treatment (P <0.05); after 4 weeks of treatment and 8 weeks of treatment , The difference between the two groups was statistically significant (P <0.05). After 8 weeks of treatment, the scores of neurological deficits and MBI in both groups were significantly improved compared with those before treatment, and the improvement in observation group was better than that in control group (P <0.05). Conclusion: Paroxetine hydrochloride has definite antidepressant effects on patients with depression after stroke, and can promote the recovery of neurological function, improve the daily activities and medication safety of patients.