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目的:探讨冠状动脉粥样硬化性心脏病(CHD)病人血清中脂联素与可溶性细胞间黏附分子-1(sICAM-1)水平的变化及临床意义。方法:选择冠心病病人59例,其中急性冠脉综合征(ACS)31例,稳定性心绞痛(SAP)28例,采用ELISA法检测病人血清脂联素、sICAM-1的浓度并与20例健康对照比较。结果:ACS组病人血清脂联素的浓度显著低于SAP组和对照组(P<0.05),sICAM-1浓度显著高于SAP组和对照组(P<0.05),血清脂联素的浓度与sICAM-1水平呈负相关(r=-0.295,P<0.05)。结论:血清脂联素与sICAM-1水平的变化与冠脉病变的稳定性有关,检测血清中脂联素与sICAM-1对于冠心病的辅助诊断、病情判断、及预防治疗有重要临床意义。
Objective: To investigate the changes of serum sICAM-1 and its clinical significance in patients with coronary atherosclerotic heart disease (CHD). Methods: Fifty-nine patients with coronary heart disease were selected, including 31 cases of acute coronary syndrome (ACS) and 28 cases of stable angina (SAP). Serum levels of adiponectin and sICAM-1 were measured by ELISA. Comparison comparison. Results: The concentration of serum adiponectin in ACS group was significantly lower than that in SAP group and control group (P <0.05). The concentration of sICAM-1 in ACS group was significantly higher than that in SAP group and control group (P <0.05) sICAM-1 levels were negatively correlated (r = -0.295, P <0.05). Conclusion: The changes of serum adiponectin and sICAM-1 levels are related to the stability of coronary artery disease. It is of great clinical significance to detect serum adiponectin and sICAM-1 in the diagnosis, diagnosis and prevention of coronary heart disease.