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在血吸虫病中,虫卵肉芽肿的形成是慢性血吸虫病的开始。肉芽肿的形成,依赖于MHC-Ⅱ类限制性CD4~+ Th细胞介导的抗虫卵抗原的特异性免疫反应,在Th1或Th2细胞因子为主的环境下都可以发生。
In schistosomiasis, the formation of egg granulomas is the beginning of chronic schistosomiasis. The formation of granuloma depends on the specific immune response mediated by MHC class II restricted CD4 ~ + Th cells and the anti-worm egg antigen, which can occur in Th1 or Th2 cytokine-dominated environment.