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目的：观察大承气汤对兔内毒素休克血清溶菌酶活性的影响。方法：血清溶菌酶活性的测定采用分光光度法，测定波长为５２０ｎｍ。结果：静脉注射大肠杆菌毒素（４０μｇ／Ｋｇ）的家兔血清溶菌酶活性较生理盐水对照组明显升高（Ｐ＜０．０１）。经大承气汤（１０ｍｌ／ｋｇ）口服给药预防３ｄ，治疗２ｄ的家免，血清溶菌酶活性较内毒素模型组明显降低（Ｐ＜０．０５），而接近正常水平。结论：大承气汤通过其消炎、抗菌、抑制内毒素吸收及稳定细胞膜等作用使溶菌酶活性恢复正常
Objective: To observe the effect of Dachengqi Decoction on serum lysozyme activity in rabbit endotoxin shock. Methods: Serum lysozyme activity was measured by spectrophotometry at a wavelength of 520 nm. RESULTS: The serum lysozyme activity of rabbits injected with E. coli toxin (40μg/Kg) was significantly higher than that of control group (P<0.01). After Dachengqi Decoction (10ml/kg) was orally administered for 3 days, the serum lysozyme activity was significantly lower (P<0.05) than that of the endotoxin model group after being treated for 2 days. Conclusion: Dachengqi Decoction restores normal lysozyme activity through its anti-inflammatory, antibacterial, and endotoxin absorption inhibition and stabilization of cell membranes.