论文部分内容阅读
滑膜浆细胞产生病理性自身抗体是类风湿关节炎(rheumatoid arthritis,RA)的特征之一。RA滑膜异位淋巴组织新生和局部自身免疫有潜在关联。未折叠蛋白反应(unfolded protein response,UPR)对于分泌免疫球蛋白的浆细胞形成具有关键作用。本文旨在探讨RA炎性周围关节浆细胞UPR与RA滑膜炎组织病理分型以及局部病理性自身抗体产生的相互关系。RA滑膜按组织病理学分型可分为滤泡型和弥散型滑膜炎。我们采用免疫
Synovial plasma cells produce pathological autoantibodies are one of the characteristics of rheumatoid arthritis (RA). RA synovial ectopic lymphoid tissue is potentially associated with local autoimmunity. Unfolded protein response (UPR) is critical for the formation of plasma cells that secrete immunoglobulins. This article aims to investigate the relationship between UPR and RA synovitis histopathological types and pathological autoantibodies in RA inflammatory periarterial synovial cells. RA synovial histopathological classification can be divided into follicular and diffuse synovitis. We use immunization