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观察了不同浓度的α１受体阻断剂盐酸哌唑嗪（ＰＺ）家兔点眼的降眼压作用，通过ＰＺ与α１受体激动剂盐酸去氧肾上腺素（ＰＥ）点眼的相互影响，探讨了ＰＺ降眼压的受体作用机理。结果显示：ＰＺ点眼后２ｈ眼压下降最显著，０．０１％、０．１％和１．０％３种浓度分别使眼压下降了０．３７ｋＰａ、０．６５ｋＰａ和０．９１ｋＰａ。１．０％ＰＥ前处理明显减弱了０．１％ＰＺ的降眼压作用，而０．１％ＰＺ前处理只拮抗１．０％ＰＥ升高眼压的作用，说明对眼压瞳孔的作用分别通过α１受体的不同亚型，进而提出在家兔眼中存在α１受体的“眼压亚型”和“瞳孔亚型”，ＰＺ降眼压的受体作用在于只阻断了α１受体的“眼压亚型”。
We observed the intraocular pressure-lowering effect of prazosin hydrochloride (PZ) in rabbits with different concentrations of α1 receptor antagonist. Through the interaction between PZ and phenylephrine hydrochloride (PE) Receptors Mechanism of PZ Intraocular Pressure. The results showed that the intraocular pressure (IOP) decreased most significantly at 2h after PZ, and the intraocular pressure decreased by 0.37kPa, 0.65kPa and 0.91kPa respectively at the concentrations of 0.01%, 0.1% and 1.0%. Pretreatment with 1.0% PE significantly decreased the intraocular pressure (IOP) by 0.1% PZ, while pretreatment with 0.1% PZ only antagonized the effect of 1.0% PE on intraocular pressure, indicating the effect on intraocular pressure pupil Respectively, through the different subtypes of α1 receptor, and then put forward the presence of α1 receptor in the rabbit eye “subocular pressure” and “pupillary subtype”, PZ intraocular pressure receptor role is only blocked α1 receptor The “subocular pressure subtype.”