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目的探讨小肠间质瘤的临床表现、诊断及治疗。方法回顾性分析1998-09-2010-01收治的29例小肠间质瘤的临床资料。结果发病年龄41~79(53±4.4)岁,消化道出血、腹部包块为最常见的临床表现;B超、CT及DSA对小肠间质瘤检出率较高;随访2个月~10 a,平均(61.8±5.6)个月,1、3、5 a无病生存率分别为92.5%、63.8%、55.6%,1、35、a总体生存率96.9%、71.7%、65.9%。结论合理的辅助检查可提高其检出率,手术为本病的最佳选择,格列卫(甲磺酸伊马替尼)对晚期小肠间质瘤有较好疗效。
Objective To investigate the clinical manifestations, diagnosis and treatment of intestinal stromal tumors. Methods The clinical data of 29 patients with small intestinal stromal tumors admitted to our hospital from September 1998 to October 2010 were retrospectively analyzed. Results The age of onset was 41-79 (53 ± 4.4) years. Gastrointestinal hemorrhage and abdominal masses were the most common clinical manifestations. The detection rates of B-ultrasound, CT and DSA were higher in small intestinal stromal tumors. The follow-up ranged from 2 months to 10 a, the average (61.8 ± 5.6) months, 1,3,5 a disease-free survival rates were 92.5%, 63.8%, 55.6%, 1,35, a overall survival rate of 96.9%, 71.7%, 65.9%. Conclusion The reasonable auxiliary examination can improve the detection rate and the best choice for surgery. Gleevec (imatinib mesylate) has a good effect on advanced small intestinal stromal tumors.