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目的:探讨预混胰岛素与二甲双胍联合治疗肥胖型糖尿病患者的疗效。方法:将126例患者随机分成两组,治疗组和对照组,每组63例。对照组应用优降糖治疗,治疗组应用预混胰岛素联合二甲双胍治疗。观察治疗前后两组血糖、甘油三酯(TG)、总胆固醇(TC)等指标的变化。结果:联合治疗后空腹血糖、餐后2h血糖、甘油三酯、胆固醇均明显下降,差异有统计学意义(P<0.05)。结论:预混胰岛素联合二甲双胍能够更好的治疗2型糖尿病。
Objective: To investigate the efficacy of premixed insulin and metformin in the treatment of obese diabetic patients. Methods: 126 patients were randomly divided into two groups, treatment group and control group, 63 cases in each group. The control group with glyburide treatment, the treatment group with premixed insulin and metformin treatment. The changes of blood sugar, triglyceride (TG) and total cholesterol (TC) were observed before and after treatment. Results: Fasting plasma glucose, 2h postprandial blood glucose, triglyceride and cholesterol decreased significantly (P <0.05). Conclusion: Pre-mixed insulin plus metformin is better for type 2 diabetes.