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目的探讨120例乙型肝炎疫苗免疫无应答再次接种后免疫效果。方法选取我院2013年2月至2014年2月收治的120例乙型肝炎疫苗接种后无应答患者,对本组患者注入3针乙型肝炎疫苗,每针20μg。90 d后,对本组患者采血分离血清,抗-HBs用固相放射免疫法(RLA)进行测定。结果本组患者进行再次免疫后,104例(86.7%)抗-HBs转为阳性。不同年龄段的抗-HBs滴度和抗-HBs阳转率分布不均,其中35~45岁、25~34岁年龄段抗-HBs阳转率达到90%以上,而各年龄间抗-HBs阳转率差异无统计学意义(χ2=0.423,P>0.05)。结论对于乙型肝炎疫苗免疫无应答患者再次接种后效果较佳,保护性抗体较高,但随着时间的延长,抗-HBs水平会逐步下降,对于复种者可以进行相应的抗-HBs滴度检测。
Objective To investigate the immune effect of 120 hepatitis B vaccines without vaccination after re-vaccination. Methods A total of 120 patients without response after hepatitis B vaccination were selected from February 2013 to February 2014 in our hospital. The patients were injected with 3 doses of hepatitis B vaccine (20μg per needle). After 90 days, blood serum was separated from the patients and anti-HBs were determined by solid phase radioimmunoassay (RLA). Results In this group of patients after re-immunization, 104 cases (86.7%) anti-HBs turned positive. Anti-HBs titers and anti-HBs positive rate were unevenly distributed in different age groups. The anti-HBs positive rate of 35-45 years old and 25-34 years old reached more than 90%, while the anti-HBs There was no significant difference in positive rate (χ2 = 0.423, P> 0.05). Conclusion The response to hepatitis B vaccination in patients with no response after vaccination is better and protective antibodies are higher, but with the extension of time, the level of anti-HBs will gradually decline, and the corresponding anti-HBs titers Detection.