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目的:探讨难治性哮喘患者支气管肺泡灌洗液中IL-5和IL-13表达和意义。方法:观察38例难治性哮喘患者经BAL术治疗前后症状、体征改变情况,并检测患者急性加重期和缓解期肺泡灌洗液中IL-5和IL-13含量,比较上述指标的变化情况。结果:(1)难治性哮喘患者行BAL术后症状、体征等临床指标较治疗前改善明显;(2)患者急性加重期肺泡灌洗液中IL-5和IL-13水平较缓解期明显增高(P<0.01)。结论:(1)支气管灌洗治疗可有效缓解哮喘症状;(2)IL-5和IL-13参与了哮喘的发病,其水平对于重症支气管哮喘急性发作诊断治疗有重要意义。
Objective: To investigate the expression and significance of IL-5 and IL-13 in bronchoalveolar lavage fluid in patients with refractory asthma. Methods: The changes of symptoms and signs before and after treatment of BAL were observed in 38 patients with refractory asthma. The levels of IL-5 and IL-13 in BALF were detected in patients with acute exacerbation and remission, and the changes of these indexes were compared . Results: (1) Patients with refractory asthma had better clinical symptoms such as signs and symptoms after BAL than those before treatment; (2) The levels of IL-5 and IL-13 in bronchoalveolar lavage fluid in patients with acute exacerbation were significantly higher than those in remission Increased (P <0.01). Conclusion: (1) Bronchoalveolar lavage can effectively relieve asthma symptoms; (2) IL-5 and IL-13 are involved in the pathogenesis of asthma. The levels of IL-5 and IL-13 play an important role in the diagnosis and treatment of severe bronchial asthma.