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多脏器功能衰竭(MOF)仍是ICU临床中的第二大死因,在美国每年约有10万人因此死亡.对MOF的实验研究虽有了一些进展,一些介质,如巨噬细胞产物、补体、前列腺素等都被认为与MOF的发生发展有关.但迄今为止实验室还缺少一个适当的动物模型,以利于研究的进行.1986年Goris等介绍了一种应用腹腔注射酵母多醣A(Zymosan A)诱发的鼠模型,酵母多醣A引发局部严重炎症,使早期发热、氧耗增加、呼吸困难、
Multiple organ failure (MOF) remains the second leading cause of death in ICU clinics, with about 100,000 deaths each year in the United States.Although some advances have been made in the experimental study of MOF, some media such as macrophage products, Complement and prostaglandin are all considered to be involved in the development of MOF, but to date, there is a lack of an appropriate animal model in the laboratory to facilitate the research.In 1986, Goris et al. Introduced a method of using intraperitoneal injection of Zymosan A) induced rat model, Zymosan A triggers severe localized inflammation leading to early fever, increased oxygen consumption, dyspnea,