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目的探讨跨声门癌的定义及局部浸润扩展的组织病理学特点，明确跨声门癌与喉癌的跨声门侵犯的区别。方法５０例跨声门癌喉全切除标本，火棉胶包埋，制成连续切片，ＨＥ染色，光镜下观察。结果５０例中，喉室全部受累，肿瘤主体位于喉室或以喉室为中心，浸润声门旁间隙者占８２％（４１／５０）。浸润方式中，粘膜下深层浸润占５２％（２６／５０），粘膜下深层浸润伴粘膜表面浸润占３８％（１９／５０），沿粘膜表面浸润占１０％（５／５０）。跨声门癌以粘膜下深层浸润为主要方式占９０％（４５／５０），向声门上区、声门区呈基本均等态势浸润扩展。结论跨声门癌系原发喉室，以此为中心纵向跨区发展的恶性肿瘤。其组织学特点为以粘膜下深层浸润为主要扩展方式。而跨声门侵犯系喉癌的晚期病变，两者有本质区别。
Objective To explore the definition of trans-glottic cancer and the histopathological features of local infiltration expansion, and clarify the difference between transglottic invasion of transglottic cancer and laryngeal cancer. Methods Totally 50 cases of transnasal laryngeal cancer were enrolled in this study. Results In 50 cases, all of the throats were involved. The main tumor located in the throat or the throat was the center, infiltrating the glottic space accounted for 82% (41/50). In the infiltration method, submucosal deep infiltration accounted for 52% (26/50), submucosal deep infiltration with mucosal surface infiltration accounted for 38% (19/50), along the mucosal surface infiltration accounted for 10% (5/50). Transglottic cancer with submucosal deep infiltration as the main method accounted for 90% (45/50), to the glottis area, the glottis area was basically equal infiltration expansion. Conclusions Transglottic cancer is a primary malignant tumor that develops longitudinally transversely across the glenoid cavity. Its histological features to submucosal deep infiltration as the main way to expand. Transjuncal invasion of laryngeal cancer of advanced disease, there is an essential difference between the two.