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目的评价香丹注射液合低分子肝素钙治疗不稳定型心绞痛的临床效果及不良反应。方法将99例不稳定型心绞痛患者随机分为两组,现察组50例,在常规药物治疗的基础上给予低分子肝素钙4100U腹壁皮下注射.每12小时一次,香丹注射液20ml加入5%GS或0.9%NS250ml中静滴。qd,疗程10天。对照组49例,在常规药物治疗的基础上给予硝酸甘油注射液10～20mg加入5%GS或0.9%NS250ml～500ml中静滴,每日一次,疗程10天,一疗程后观察临床效果及不良良反应。结果观察组有效率92%,对照组有效率69.37%,两组治疗效果差异有显著性(P<0.05)。观察组明显优于对照组,且不良反应少。结论香丹注射液合低分子肝素钙治疗不稳定型心绞痛疗效好,不良反应少,方法简单,使用安全、方便,用药期间不依赖实验室监测,值得推广应用。
Objective To evaluate the clinical effects and adverse reactions of Xiangdan Injection combined with low molecular weight heparin in the treatment of unstable angina pectoris. Methods 99 patients with unstable angina pectoris were randomly divided into two groups, the observation group of 50 patients on the basis of conventional drug therapy given low molecular weight heparin 4100U abdominal subcutaneous injection once every 12 hours Xiangdan injection 20ml added 5 % GS or 0.9% NS250ml intravenous infusion. qd, treatment for 10 days. In the control group, 49 cases were given intravenous drip of 10-20mg of nitroglycerin injection or 5% GS or 0.9% NS250ml-500ml on the basis of routine drug treatment once a day for 10 days. After a course of treatment, the clinical effects and adverse effects were observed Good reaction. Results The effective rate of the observation group was 92%, while that of the control group was 69.37%. The difference between the two groups was significant (P <0.05). Observation group was significantly better than the control group, and adverse reactions less. Conclusion Xiangdan injection combined with low-molecular-weight heparin calcium in the treatment of unstable angina pectoris has good curative effect, less adverse reactions, simple method, safe and convenient use, and does not rely on laboratory monitoring during the treatment, which deserved to be popularized and applied.