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目的:探索普贝生——控释前列腺素E_2栓剂用于足月妊娠促宫颈成熟、催产的有效性和安全性。方法:采用随机抽查、对照研究的方法,50例为研究组,予阴道放置普贝生观察;50例对照组,予静脉滴注催产素观察。比较2组孕妇宫颈Bishop评分,分娩情况,对胎儿及新生儿的影响。结果:研究组孕妇用药后2、4、8、12小时宫颈Bishop评分分别为4.0±1.3、4.2±1.2、6.0±1.1和7.6±1.7,明显高于对照组3.7±1.4、3.8±0.8、4.1±1.1和4.6±1.2(P<0.01)。研究组孕妇临产发动时间、阴道分娩率明显高于对照组(P<0.01)。产程中研究组胎儿窘迫发生率、出生后1分钟、5分钟Apgan评分与对照组之间无统计学差异(p>0.05)。宫缩过度刺激是普贝生的主要副作用,但取药后可立即好转。结论:普贝生是一种有效、安全的促宫颈成熟的药物。
OBJECTIVE: To explore the effectiveness and safety of pubezheng-controlled release prostaglandin E_2 suppository for cervical ripening and oxytocin during term pregnancy. Methods: Randomized randomized controlled study, 50 cases of study group, placed in the vagina Plesi observed; 50 cases of control group, intravenous infusion of oxytocin observation. The Bishop cervical score, delivery status, fetal and neonatal effects in two groups were compared. Results: The Bishop scores at 4, 6, 8 and 12 hours after treatment in the study group were 4.0 ± 1.3, 4.2 ± 1.2, 6.0 ± 1.1 and 7.6 ± 1.7, respectively, which were significantly higher than those in the control group 3.7 ± 1.4, 3.8 ± 0.8 and 4.1 ± 1.1 and 4.6 ± 1.2 (P <0.01). The study group pregnant women labor onset time, vaginal delivery rate was significantly higher than the control group (P <0.01). The incidence of fetal distress in the study group during labor was not statistically different between the 1-minute and 5-minute post-birth Apgan scores and the control group (p> 0.05). Uterotonic over-stimulation is the main side effects of P Bei students, but after taking the drug can be immediately improved. Conclusion: Przewalski is an effective and safe cervical ripening drug.