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有P菌毛的大肠杆菌粘附于尿路上皮细胞α-D-半乳糖-(1-4)-β-D-半乳糖(Gal-Gal)受体上是发生肾盂肾炎的一种重要发病机理。曾发现用P菌毛免疫可预防大肠杆菌感染,但菌毛纯化过程不易将菌毛与内毒素分离。目前乙型肝炎病毒(HBV)、非洲锥虫抗独特型抗体被作为疫苗研究产生保护性抗体。作者制备大肠杆菌P菌毛独特型抗体在肾盂肾炎猴幼物模型中研究其保护作用。用Ga1-Gal交联牛血清白蛋白免疫兔及猴均产
Escherichia coli with P-pilus adhered to the urinary epithelial cell α-D-galactose- (1-4) -β-D-galactose (Gal-Gal) receptor is an important pathogenesis of pyelonephritis mechanism. P pilus was found to be immune to E. coli infection, but the pili purification process is not easy to separate the pili and endotoxin. Currently, Hepatitis B virus (HBV) and African trypanosome anti-idiotypic antibodies are being developed as vaccines to produce protective antibodies. The authors prepared Escherichia coli P-type pili specific antibodies in pyramidal neurons of young pig model to study its protective effect. Rabbits and monkeys were immunized with Ga1-Gal cross-linked bovine serum albumin