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目的 评价肝素对儿童肾炎性肾病综合征（ＮＮＳ） 的远期疗效。方法 在常规治疗的基础上，治疗组３５ 例患儿加用肝素钙５０Ｕ／（ｋｇ·ｄ） 静滴，同期未用肝素的３０ 例为对照组。观察两组治疗前后的尿纤维蛋白降解产物（ＦＤＰ）变化并随访１－５～５－５ 年。结果 治疗４～６ 周后尿ＦＤＰ水平治疗组显著低于对照组（ Ｐ＜０－０１），完全缓解者显著低于部分缓解者（ Ｐ＜０－０１）。完全缓解率为治疗组８８－５７％ ，对照组５３－３３％ ，两组对比差异显著（ Ｐ＜０－０５）。结论 对ＮＮＳ患儿加用肝素钙治疗可使尿ＦＤＰ减少，缓解率提高且治疗后尿ＦＤＰ降低明显者远期疗效较好。
Objective To evaluate the long-term effect of heparin on children with nephritic nephrotic syndrome (NNS). Methods On the basis of routine treatment, 35 children in the treatment group received intravenous infusion of heparin 50U / (kg · d), and 30 patients who did not use heparin during the same period as the control group. The changes of urinary fibrin degradation products (FDP) before and after treatment in both groups were observed and followed up for 1-5-5-5 years. Results After 4 to 6 weeks of treatment, the urinary FDP level in the treatment group was significantly lower than that in the control group (P <0-01), and the complete remission was significantly lower than that in the partial remission (P <0-01). The complete remission rate was 88-57% in the treatment group and 53-33% in the control group, with significant difference between the two groups (P <0-05). Conclusion Heparin calcium treatment in children with NNS can reduce the urinary FDP, improve the response rate and treatment of urinary FDP decreased significantly better long-term efficacy.