Antisense oligonucleotide targeting at the initiator of hTERT arrests growth of hepatoma cells

• 作 者: Su-XiaLiu Wen-ShengSun Ying-Li
• 机 构: InstituteofImmunology
• 出 处: 世界胃肠病学杂志：英文版（电子版）
• 发表日期: 2004年3期
• 关键词: 肝细胞癌 肿瘤细胞 反义寡核苷酸 肿瘤抑制 端粒酶 乙型肝炎病毒
• 基金项目: Supported by the National Natural Science Foundation of China,No.30070341

AIM:To evaluate the inhibitory effect of antisense phosphorothioate oligonucleotide (asON) complementary to the initiator of human telomerase catalytic subunit (hTERT) on the growth of hepatoma cells.METHODS:The as-hTERT was synthesized by using a DNA syn