论文部分内容阅读
根据神经病理观察,长期以来认为垂体腺瘤的自发性坏死(垂体卒中)是一种威胁患者生命的疾病。作者的研究证明本病常有一个良性的过程,大部分病例可以没有肿瘤包膜的破裂,脑脊液中也没有任何脑膜反应,症状常会自发性消退。作者报告1970年以来经手术和组织学证实的586例垂体瘤中,72例(12.3%)有张力性囊性变的坏死区,多数伴有出血。这72例中62例(10.6%)肿瘤包膜没有破裂,10例的肿瘤包膜破裂,表现为脑脊液血性,黄变和/或含有白细胞。垂体肿瘤的自发性坏死最常见于内分泌不活跃的腺瘤中,几乎60%发生于过去未被分类的催乳素腺瘤中。586例垂体腺瘤中,内分泌不活跃的腺瘤(包括催乳素腺瘤)280例,其中无破裂的肿瘤坏死53例(18.9%)有破裂的肿瘤坏死
According to neuropathological observations, spontaneous necrosis of pituitary adenomas (pituitary apoplexy) has long been considered a life-threatening disease. The author’s studies have shown that this disease often has a benign process, most cases can be without rupture of the tumor capsule, there is no meningeal reaction in the cerebrospinal fluid, and the symptoms often spontaneously subside. The authors report that in 586 cases of pituitary tumors that had been confirmed by surgery and histology since 1970, 72 (12.3%) had necrotic areas of tension cystic degeneration, most of them accompanied by hemorrhage. In these 72 cases, 62 cases (10.6%) had no rupture of the tumor capsule, and 10 cases of the tumor capsule ruptured, showing cerebrospinal fluidity, yellowing, and/or white blood cells. The spontaneous necrosis of pituitary tumors is most common in endocrine inactive adenomas, and almost 60% occurs in previously unclassified prolactinomas. In 586 cases of pituitary adenomas, 280 cases of endocrine inactive adenomas (including prolactin adenomas), 53 of which had no ruptured necrosis (18.9%) had ruptured tumor necrosis.