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本文采用随机双盲方法对比了腺苷与三磷酸腺苷(ATP)治疗室上性心动过速(SVT)的临床疗效、副作用的发生率及其严重程度。 39例患者共发生SVT68例次,心率为每分钟120～230次。所有患者均在进入本研究前24小时停用一切药物。用药方法为1秒钟内快速静注腺苷或ATP 2.5～20mg。结果表明,27例次SVT患者,静注腺苷平均22秒钟后,20例次转为窦性节律,9例次转为房性心律失常。静注ATP的25例次患者,22例次转为窦性节律、6例次转为房性心律失常,ATP的有效时间亦平均为22秒钟。腺苷与ATP的有效剂量分别为3.8mg、6.6mg(p<0.05)。经周围静脉给予腺
In this paper, the clinical efficacy of adenosine and adenosine triphosphate (ATP) in the treatment of supraventricular tachycardia (SVT) was compared by randomized double-blind method, the incidence and severity of side effects. A total of 68 SVTs occurred in 39 patients with a heart rate of 120 to 230 beats per minute. All patients discontinued all medication 24 hours prior to entering the study. Medication method is rapid intravenous infusion of adenosine or ATP 2.5 ~ 20mg within 1 second. The results showed that in 27 patients with SVT, intravenous adenosine averaged 22 seconds, 20 cases turned to sinus rhythm, and 9 cases turned to atrial arrhythmia. Twenty-five episodes of intravenous ATP were switched to sinus rhythm, followed by 6 episodes of atrial arrhythmia. The mean ATP duration was 22 seconds. Effective doses of adenosine and ATP were 3.8 mg and 6.6 mg, respectively (p <0.05). Giving the gland via peripheral vein