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通过测定卵巢早衰(POF)患者血清雄激素前身物,中间产物及最终产物水平,与卵巢功能正常的妇女比较,对POF患者肾上腺及卵巢的类固醇生成能力的改变进行推论。 观察对象为特发性卵巢早衰患者7例,年龄为20～34岁;另选6例年龄在27～29岁,早期滤泡期检查卵巢功能正常的妇女作对照。 用RIA测定血清Δ~5前身物:孕烯醇酮、17-羟孕烯醇酮、脱氢表雄酮;Δ~4中间产物:孕酮、17-羟孕酮、雄烯二酮及最终产物:睾酮、雌二醇及皮
By measuring the level of serum androgen precursors, intermediates and final products in patients with premature ovarian failure (POF), the changes of steroidogenic capacity in the adrenal gland and ovary in POF patients were compared with those in normal ovarian function. Seven patients with idiopathic premature ovarian failure were observed, aged from 20 to 34 years old. Another 6 women aged 27 to 29 years old with early ovarian follicular function were examined as normal controls. Progesterone, 17-hydroxypregnenolone and dehydroepiandrosterone were measured by RIA; serums of Δ 4 were progesterone, 17-hydroxyprogesterone, androstenedione and finally Products: Testosterone, Estradiol and Skin