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探讨重型颅脑损伤监测降钙素原和超敏C反应蛋白对感染的鉴别诊断应用。选择我院2015年1月至2016年1月所接诊的80例重型颅脑损伤患者,其中40例伴有肺部感染作为感染组,其余40例为未感染组,在感染当天检测降钙素原(PCT)、超敏C反应蛋白(hs-CRP)水平,感染组患者给予相应的抗感染治疗后,根据患者感染情况进行分组,在感染后3 d、感染后7 d时分别对PCT、hs-CRP水平进行检测。在感染当天,感染组PCT、hs-CRP水平均比未感染组高((3.85±0.51)ng/m L比(0.53±0.15)ng/m L,(61.23±17.34)mg/L比(50.12±13.12)mg/L)(p<0.05);在感染组患者中,24例患者感染好转,感染后3 d、感染后7 d时,PCT、hs-CRP水平均比确认感染当天得到降低(p<0.05);另外16例患者感染持续,在感染后3 d、感染后7 d时,PCT、hs-CRP水平均发生持续性升高,与确认感染当天比较差异具有统计学意义(p<0.05)。PCT和hs-CRP的检测在重型颅脑损伤并发肺部感染患者中具有较高的特异性敏感性,有利于临床评估。
To investigate the differential diagnosis of severe craniocerebral injury monitoring of procalcitonin and high-sensitivity C-reactive protein infection. Eighty patients with severe craniocerebral injury who were admitted to our hospital from January 2015 to January 2016 were selected, of whom 40 had pulmonary infection as the infection group and the remaining 40 as uninfected group. On the day of infection, The levels of PCT, hs-CRP in the infected group were given corresponding anti-infective therapy, and then grouped according to the patient’s infection. At 3 d after infection and 7 d after infection, , Hs-CRP levels were detected. On the day of infection, the levels of PCT and hs-CRP in the infected group were significantly higher than those in the non-infected group (3.85 ± 0.51 ng / m L vs 0.53 ± 0.15 ng / m L, (61.23 ± 17.34) mg / L vs ± 13.12) mg / L) (p <0.05). In the infected group, the infection of 24 patients improved, and the PCT and hs-CRP levels decreased on the 3rd day and 7th day after infection p <0.05). In the other 16 patients, the infection persisted. The levels of PCT and hs-CRP persisted at 3 days and 7 days after infection, respectively, with significant difference from the day of confirmed infection (p < 0.05). The detection of PCT and hs-CRP in patients with severe craniocerebral injury complicated with lung infection has a high specificity and sensitivity, which is conducive to clinical evaluation.