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研究脑梗死患者血细胞流变学、红细胞膜流动性、变形性、血小板活化聚集、胆固醇结晶及循环内凝团块含量与脑梗死的病理关系。采用美国布氏多功能显微镜的活血分析法,在高放大倍数[1.5万倍]下直接观察红细胞、血小板、胆固醇结晶及活性血栓的细胞流变学情况及变形性。研究表明两组相比有明显的差异性,红细胞呈串珠样改变,其变形能力差、膜流性减低(P<0.05),血粘度高,血小板聚集率增高,循环内凝块增多,两组相比P<0.01。血流变学改变、红细胞串珠样改变、红细胞膜变形性减低、血小板聚集率增高,血浆粘度及流动栓子增多是脑梗死发病的重要病理基础。临床上应对血液成分进行积极研究和探讨,为缺血性脑血管病的预防、诊断、治疗以及预后判断等,提供重要的资料及实际意义。
To study the relationship between hemocyte rheology, erythrocyte membrane fluidity, deformability, platelet activation and aggregation, cholesterol crystallization and the content of circulating clot and cerebral infarction in patients with cerebral infarction. The use of the United States Brinell’s multi-function microscope blood analysis, direct observation of red blood cells, platelets, cholesterol crystals and active thrombosis cell rheology and deformability at high magnification [15000 times]. Studies have shown that there were significant differences between the two groups, red blood cells were beaded like changes in its poor ability to deform, membrane flow decreased (P <0.05), high blood viscosity, increased platelet aggregation, increased clot circulation, P <0.01 for both groups. Changes in hemorheology, alteration of erythrocyte beaded, reduction of erythrocyte membrane deformability, increased platelet aggregation rate, increased plasma viscosity and flow emboli are important pathological basis for the pathogenesis of cerebral infarction. The clinical response to the blood composition of active research and discussion for the prevention, diagnosis, treatment and prognosis of ischemic cerebrovascular disease provide important information and practical significance.