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目的：定量分析粪卟啉异构体．方法：利用反相高效液相色谱法（ＲＰ－ＨＰＬＣ）对１４例迟发性皮肤卟啉病（ＰＣＴ）、１５例急性间歇性卟啉病（ＡＩＰ）、９例杜宾－约翰逊综合症（ＤＪＳ）和３５例正常健康者的尿液和粪便中的粪卟啉异构体Ⅰ和Ⅲ进行定量分析。结果：发现ＡＩＰ、ＤＪＳ和ＰＣＴ患者的尿液和粪便中粪卟啉异构体Ⅰ和Ⅲ与正常健康者相比均发生不同程度的变化。结论：该方法灵敏度高，再现性好，在临床上具有推广应用的价值。
Objective: To quantitatively analyze the isoporphyrin isomers. Methods: The clinical data of 14 patients with delayed skin porphyria (PCT), 15 patients with acute intermittent porphyria (AIP), 9 patients with Duchenne-Johnson syndrome (RPE) were analyzed by reverse-phase high performance liquid chromatography DJS) and urine and feces of 35 healthy controls were used for quantitative analysis of the coproporphyrins I and III. RESULTS: It was found that the urine and feces of AIP, DJS and PCT patients, Ⅰ and Ⅲ, were different from those in normal controls. Conclusion: The method has high sensitivity, good reproducibility and is clinically valuable in popularization and application.