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醛固酮能阻止去甲肾上腺素摄取和促发心肌重构,醛固酮受体拮抗剂螺内酯却能改善扩张型心肌病(DCM)患者的左室(LV)重构,但其对心脏交感神经活性的作用尚未清楚。本文拟螺内酯对DCM患者心脏交感神经活性以及LV重构的可能作用进行了评价。对象与方法 30例DCM患者,男17例,女13例,平均年龄65±15岁,心功能属NYHAⅡ～Ⅲ级。研究前均已接受了ACEI、袢利尿剂、或地高辛和血管扩张剂治疗。研究中分为随机加服螺内酯(25mg/d)的治疗组和未加服螺内酯的对照组各15例,疗程半年。并于治疗前后分别经放射性~(123)Ⅰ-标志
Aldosterone prevents norepinephrine uptake and promotes cardiac remodeling, and the aldosterone receptor antagonist spironolactone improves left ventricular remodeling in patients with dilated cardiomyopathy (DCM) but its effect on cardiac sympathetic nerve activity Not yet clear. In this paper, spironolactone on cardiac sympathetic activity in patients with DCM and the possible role of LV remodeling were evaluated. Subjects and Methods 30 cases of DCM patients, 17 males and 13 females, mean age 65 ± 15 years, NYHA Ⅱ ~ Ⅲ heart function. Before the study have been accepted ACEI, 袢 diuretics, or digoxin and vasodilator treatment. The study was divided into random plus spironolactone (25mg / d) and no spironolactone control group 15 cases each treatment for six months. And before and after treatment by radioactive ~ (123) Ⅰ-mark