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目的合成生物素化硫酸软骨素多糖衍生物并制备纳米粒。方法生物素和硫酸软骨素多糖进行酯化反应,得到疏水改性的衍生物,傅立叶红外光谱仪对其表征;采用高压均质法制备衍生物纳米粒,以粒径、多分散系数为评价指标,星点设计-效应面法优化处方。结果优化后的硫酸软骨素多糖衍生物纳米粒的粒径为(108.04±23)nm,分散系数为(0.182±0.03)。结论生物素和硫酸软骨素多糖以酯键连接在一起,合成了生物素化硫酸软骨素多糖衍生物。合成的衍生物有望成为疏水药物的载体。
Objective To synthesize biotinylated chondroitin sulfate polysaccharide derivatives and prepare nanoparticles. Methods Biotin and chondroitin sulfate polysaccharide were esterified to obtain hydrophobic modified derivatives, which were characterized by Fourier transform infrared (FTIR) spectroscopy. The nanoparticles were prepared by high pressure homogenization method. The particle size and polydispersity index were used as evaluation indexes. Star design - response surface optimization prescription. Results The particle size of the optimized chondroitin sulfate derivative nanoparticles was (108.04 ± 23) nm and the dispersion coefficient was (0.182 ± 0.03). Conclusion Biotin and chondroitin sulfate polysaccharides are linked by ester bonds, and biotinylated chondroitin sulfate derivatives are synthesized. Synthetic derivatives are expected to become hydrophobic drug carrier.