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附子具有回阳救逆、散寒止痛之功效,治疗重症疾病中疗效独特,但具有明显的心脏毒性和神经毒性。附子存在不经炮制、煎煮时间愈短、给药量愈大,则毒性愈大、药理活性愈强的规律,但其药物作用和毒性作用在一定条件下可相互转换,不同的炮制方法可利用其毒性作用,使其转化为治疗作用。附子经较长时间煎煮后,其有毒成份会被破坏,而有效成份也随之部分流失;水溶液的镇静、镇痛、抗炎等作用随水解时间而逐渐减弱,而有效成分总乌头碱含量不会发生变化。合理的配伍,不仅可以降低附子的毒性,减少不良反应,还可增强附子疗效,使其应用范围扩大。科学、合理地控制附子使用剂量,其发生严重毒性反应的机率则非常小。
Aconite possesses the effect of returning yang, relieving cold and relieving pain, and has unique curative effect in the treatment of severe diseases, but has obvious cardiotoxicity and neurotoxicity. Aconite exists without processing, boiling time is shorter, the greater the dose, the greater the toxicity, the stronger the law of pharmacological activity, but the role of the drug and toxicity under certain conditions can be converted to each other, different methods can be prepared Use its toxic effect, make it into a therapeutic effect. Aconite after boiling for a long time, its toxic components will be destroyed, while the active ingredient also will be part of the loss; aqueous solution of sedation, analgesic, anti-inflammatory and other effects with the hydrolysis time and gradually weakened, while the active ingredient total aconitine The content will not change. Rational compatibility, not only can reduce the toxicity of aconite, reduce adverse reactions, but also enhance the efficacy of aconite, to expand its scope of application. Scientifically and rationally control the dose of aconite, the probability of serious toxic reaction is very small.