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东南亚柬、泰边境拜林的药盐计划证明,当大批恶性疟患者面临严重传播时,在强烈的药物压下,能发生药物抗性,特别是氯喹抗性。抗性原虫的选育因无免疫人群的输入而增强。药物抗性的产生是由于恶性疟原虫对乙胺嘧啶和氯喹连续、长期大量接触,导致抗性突变型的选育。这种选育如果在原虫反复通过无免疫力宿主期间,多次与很高药物剂量接触,将增加抗性的程度。通过已感染抗药性恶性疟的临时移民的流动,抗性扩散到柬埔寨和其它邻近国家的可接受性地区。在巴拉巴按蚊地区,氯喹抗性的迅速和早期扩散不是一个巧合,而是与这个按蚊种团对疟疾传播有关的生物学优势的结果。在澳大拉西亚,与巴布亚新几内亚接界的伊里安查亚执行的药盐计划,也导致了抗药性恶性疟的发生。
The salt program of the Perin in South-East Asia Cambodia and Thailand border areas proves that drug resistance, especially chloroquine resistance, can occur when a large number of patients with severe falciparum malaria are under severe drug pressure. The selection of resistant protozoa is enhanced by input from non-immunized populations. Drug resistance is due to the continuous and long term exposure of Plasmodium falciparum to pyrimethamine and chloroquine, resulting in the selection of resistant mutants. This breeding will increase the level of resistance if multiple protracted exposure to very high doses of the drug occurs while the protozoan repeatedly passes through the non-immune host. Resistance has spread to areas of acceptability in Cambodia and other neighboring countries through the flow of temporary migrants infected with resistant P. falciparum. In the area of the Anopheles Balaba, the rapid and early proliferation of chloroquine resistance is not a coincidence but a result of the biological advantages associated with the spread of malaria by this mosquito species. In Australasia, the drug program implemented in Irian Jaya, which borders with Papua New Guinea, also led to the emergence of drug-resistant falciparum malaria.