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目的探讨纳洛酮对小婴儿肺炎并充血性心力衰竭的治疗作用。方法６４例小婴儿肺炎并充血性心力衰竭病例（３个月内），随机分纳洛酮治疗组３２例和对照组３２例，治疗组在综合治疗的基础上，加用纳洛酮，按每次０．０５～０．１ｍｇ／ｋｇ静滴。结果两组症状、体征恢复正常的时间均有显著性差异。治疗组和对照组呼吸频率、心率与肝脏肿大恢复正常的时间分别为１．３９７±０．１３３天比６．９４１±０．７９３天（Ｐ＜０．００１）。治疗组显效１７例，好转１５例，有效率１００％，对照组好转２４例，有效率７５％，两组对比有显著性差异（Ｐ＜０．０１）。结论纳洛酮有保护心肌、抗心力衰竭的治疗作用。
Objective To investigate the therapeutic effect of naloxone on pneumonia and congestive heart failure in infants. Methods Sixty-four infants with pneumonia and congestive heart failure (within 3 months) were randomly divided into naloxone treatment group (n = 32) and control group (n = 32). On the basis of comprehensive treatment, Each 0.05 ~ 0.1mg / kg intravenous infusion. Results Two groups of symptoms, signs of recovery time were significant differences. Respiratory rate, heart rate and liver enlargement in the treatment group and control group returned to normal at 1.397 ± 0.133 days compared with 6.941 ± 0.793 days (P <0.001). The treatment group markedly effective in 17 cases, improved in 15 cases, the effective rate was 100%, the control group improved in 24 cases, the effective rate was 75%. There was significant difference between the two groups (P <0.01). Conclusion Naloxone can protect myocardium and prevent heart failure.