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以往的研究认为,原发前列腺肿瘤具有多灶和多克隆异质性,但大多数来自同一患者不同部位远处转移肿瘤共享大部分遗传变异,提示致死性转移癌细胞为单克隆起源。然而,近期作者应用全基因组测序和分子病理检测,分析1例死于转移性前列腺癌患者的致死细胞克隆起源却有了一些不同的发现。该患者47岁时诊断为前列腺腺癌,经根治性前列腺切
Previous studies suggested that primary prostate tumors have multifocal and polyclonal heterogeneity, but most distant metastases from different parts of the same patient share most of the genetic variation, suggesting that the lethal metastatic cancer cells are of monoclonal origin. However, recent authors using genome-wide sequencing and molecular pathology to detect the origin of the lethal cell clones in one patient who died of metastatic prostate cancer have some different findings. The patient was diagnosed with prostate adenocarcinoma at 47 years of age and underwent radical prostatectomy