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[目的]明确阿尔茨海默病(AD)与2型糖尿病(T2DM)之间是否存在共患风险。[方法]对1040名72岁以上男性部队离退休干部进行了T2DM及AD患病率调查,并分析了两种疾病之间的共患风险。[结果]共发现T2DM262名,AD29名,同时患有两种疾病者13名,T2DM者AD的患病率为4.96%,非T2DM者AD的患病率为2.06%,前者高于后者且两组间AD患病率差异具有统计学意义(χ2=6.10,P﹤0.05);AD者T2DM的患病率为44.83%,明显高于非AD者(24.63%),两组间T2DM患病率差异有统计学意义(χ2=6.10,P﹤0.05);年龄分层发现72～81岁间T2DM者AD的患病率(4.92%)显著高于非T2DM者(1.97%)并具有统计学意义(χ2=4.74,P﹤0.05),而82～92岁间T2DM者AD的患病率(5.06%)亦明显高于与非T2DM者AD的患病率(2.37%),但两组间AD患病率差异无统计学意义(χ2=0.539,P﹥0.05)。[结论]AD与T2DM在一定年龄的男性老年人中存在共患风险。
[Objective] To determine whether there is a shared risk between Alzheimer’s disease (AD) and type 2 diabetes mellitus (T2DM). [Methods] The survey of the prevalence of T2DM and AD in 1040 retired cadres of men over the age of 72 was conducted, and the common risk between the two diseases was analyzed. [Results] A total of 262 T2DM patients and AD29 were found, and 13 patients with both diseases were also found. The prevalence of AD in T2DM was 4.96% and the prevalence of AD in non-T2DM was 2.06%, the former was higher than the latter The prevalence of AD in the two groups was statistically significant (χ2 = 6.10, P <0.05). The prevalence of T2DM in AD was 44.83%, significantly higher than that in non-AD (24.63%), (Χ2 = 6.10, P <0.05). The age-matched prevalence of AD in 72- to 81-year-old T2DM patients (4.92%) was significantly higher than that of non-T2DM patients (1.97%) with statistical significance (Χ2 = 4.74, P <0.05). However, the prevalence of AD in T2DM patients was also significantly higher than that in non-T2DM patients (2.37% vs 5.06%, 82-92 years) (2.37% The prevalence of AD had no significant difference (χ2 = 0.539, P> 0.05). [Conclusion] AD and T2DM have common risk in male aged people of certain age.