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目的 探讨血清游离前列腺特异抗原 (f PSA)及游离 PSA/总前列腺特异抗原 (t PSA)比值对前列腺癌的诊断价值。方法 用酶联免疫方法检测 1 30例前列腺癌 (PCa)、76例前列腺增生 (BPH)以及 42例正常对照组的血清 f PSA、t PSA,并计算 f PSA/ t PSA比值 ,评价其对前列腺癌的诊断价值。结果 以 f PSA/ t PSA比值为 0 .1 5为评判上限时 ,前列腺癌组明显低于前列腺增生组及正常对照组 (P<0 .0 1 ) ,认为 f PSA及 f PSA/t PSA比值可有效区分 PCa和 BPH(P<0 .0 0 5) ,其诊断敏感性为 91 .6% ,特异性为 88.1 % ,准确性为 87.8% ;尤其是当 PSA值界定在 4～ 1 0μg/ L灰区范围内效果更明显优于常规的 t PSA和 f PSA单独测定结果。结论 f PSA和 f PSA/ t PSA比值的应用 ,使血清 PSA测定更具临床意义 ,提高了前列腺癌的早期诊断
Objective To investigate the diagnostic value of serum free prostate-specific antigen (f PSA) and free PSA / total prostate-specific antigen (t PSA) in prostate cancer. Methods Serum f PSA and t PSA of 130 prostate cancer (PCa), 76 benign prostatic hyperplasia (BPH) and 42 normal control group were detected by enzyme-linked immunosorbent assay (ELISA), and the ratio of f PSA / t PSA was calculated. The diagnostic value of cancer. Results When the ratio of f PSA / t PSA was 0.15, the value of f PSA and f PSA / t PSA in prostate cancer group was significantly lower than that in benign prostatic hyperplasia group and normal control group (P <0.01) The diagnostic sensitivity was 91.6%, the specificity was 88.1% and the accuracy was 87.8%. Especially when the PSA value was defined as 4 ~ 10μg / L gray zone is more effective than the conventional t PSA and f PSA alone results. Conclusion The application of f PSA and f PSA / t PSA ratio makes the determination of serum PSA more clinical significance and improves the early diagnosis of prostate cancer